Acid Base Physiology

The  normal ECF H+ concentration is 40 nanomol/L. Regulation of H+ concentration at this low level is essential for normal cellular processes because of the high reactivity of H+ ions, particularly with proteins. When there is a change in H+ concentration, proteins gain or lose H+ ions, resulting in alterations in charge distribution, molecular configuration, and consequently protein function. Under normal conditions, the H+ concentration varies little from its normal value due to the processes of acid base regulation.


This teaching module will discuss the role of acid base regulation and includes the following topics:

You may click on each topic individually. If you are taking the tutorial for the first time, it is preferable that you click next to go through the topics sequentially.